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Research project

An integrated strategy for control of animal and plant parasitic nematodes through targeting MOD-1

Staff

Lead researchers

Professor Lindy Holden-Dye BSc, MSc, PhD, FRSB, FBPhS

PROFESSOR OF NEUROSCIENCES
Research interests
  • Neuropharmacology
  • Invertebrate neuroscience
  • Nematode neurobiology
Connect with Lindy

Email: L.M.Holden-Dye@soton.ac.uk

Other researchers

Professor Matthew Terry

Professor of Molecular Plant Biology
Research interests
  • Chloroplast development and retrograde signalling to the nucleus
  • Light regulation of wheat growth and development
  • Improving algal photosynthesis
Connect with Matthew

Email: mjt@soton.ac.uk

Professor Vincent O'connor

Professor of Neurochemistry
Research interests
  • Molecular mechanism of synaptic function and dysfunction
  • Synaptic degeneration
  • Genetic models of synaptic and neuronal dysfunction
Connect with Vincent

Email: V.M.OConnor@soton.ac.uk

Professor Mark Chapman

Professor
Research interests
  • Novel and Underutilised Crops (NUCs) for climate change resilience and food security
  • The genomic bases of speciation and hybridisation
  • Domestication genomics
Connect with Mark

Email: M.Chapman@soton.ac.uk

Dr Herman Wijnen Drs, PhD, FHEA

Associate Professor
Research interests
  • Control of Daily Rhythms by Circadian Clocks and the Environment
  • Genetics, Behaviour and Neuroscience of the fruit fly Drosophila
  • Chronophysiology of Invertebrates in Association with Global Environmental Change and Food Se…
Connect with Herman

Email: H.Wijnen@soton.ac.uk

Dr Declan Doyle

Principal Teaching Fellow
Connect with Declan

Email: D.A.Doyle@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

PharmacoGenetic targeting of a C. elegans essential neuron provides an in vivo screening for novel modulators of nematode ion channel function
Fernando Calahorro, Mark Chapman, Katarzyna Dudkiewicz, Lindy Holden-dye & Vincent O'connor, 2022, Pesticide Biochemistry and Physiology, 186
DOI: 10.1016/j.pestbp.2022.105152
Type: article
Confounds of using the unc-58 selection marker highlights the importance of genotyping co-CRISPR genes
Helena Rawsthorne-Manning, Fernando Calahorro , Patricia G. Izquierdo, Philippe Tardy, Thomas Boulin, Lindy Holden-Dye, Vincent O'Connor & James Dillon, 2022, PLoS ONE, 17(1)
DOI: 10.1371/journal.pone.0253351
Type: article
Cholinergic signaling at the body wall neuromuscular junction distally inhibits feeding behavior in Caenorhabditis elegans
Patricia G. Izquierdo, Fernando Calahorro, Thibana Thisainathan, James H. Atkins, Johanna Haszczyn, Christian J. Lewis, John E.h. Tattersall, A. Christopher Green, Lindy Holden-dye & Vincent O'connor, 2022, Journal of Biological Chemistry, 298(1), 101466
DOI: 10.1016/j.jbc.2021.101466
Type: article
Impact of drug solvents on C. elegans pharyngeal pumping
Fernando Calahorro Nunez, Linda Holden-Dye & Vincent O'connor, 2021, Toxicology Reports, 8, 1240-1247
DOI: 10.1016/j.toxrep.2021.06.007
Type: article