Investigating the role of PIP4K2B, nuclear phosphoinositides and TAF3 in transcription and genome organisation during myogenic differentiation

Staff

Lead researchers

Professor Nullin Divecha

Professor of Cellular Signalling

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Research outputs

Mechanisms of SARS-CoV-2 inactivation using UVC laser radiation

George Devitt, Peter B. Johnson, Niall Hanrahan, Simon I.R. Lane, Magdalena C. Vidale, Bhavwanti Sheth, Joel D. Allen, Maria V. Humbert, Cosma M. Spalluto, Rodolphe C. Herve, Karl Staples, Jonathan J. West, Robert Forster, Nullin Divecha, Chris McCormick, Max Crispin, Nils Hempler, Graeme P.A. Malcolm & Sumeet Mahajan, 2024, ACS Photonics, 11(1), 42-52

DOI: 10.1021/acsphotonics.3c00828

Type: article

PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1

A. Poli, F.A. Pennacchio, A. Ghisleni, M. di Gennaro, M. Lecacheur, P. Nastaly, M. Crestani, F.M. Pramotton, F. Iannelli, G. Beznusenko, A. A Mironov, V. Panzetta, S. Fusco, B. Sheth, D. Poulikakos, A. Ferrari, N. Gauthier, P.A. Netti, N. Divecha & P. Maiuri, 2023, Nature Communications, 14(1)

DOI: 10.1038/s41467-023-37064-0

Type: article

Identification and optimization of a novel series of selective PIP5K inhibitors

D.M. Andrews, S. Cartic, S. Cosulich, N. Divecha, P. Faulder, V. Flemington, O. Kern, J.G. Kettle, E. MacDonald, J. McKelvie, K.G. Pike, B. Roberts, R. Rowlinson, J.M. Agnos, M. Stockley, M.E. Swarbrick, I. Treinies & M.J. Waring, 2021, Bioorganic & Medicinal Chemistry, 54

DOI: 10.1016/j.bmc.2021.116557

Type: article

PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity

Alessandro Poli, Shidqiyyah Abdul-hamid, Antonio Enrico Zaurito, Francesca Campagnoli, Valeria Bevilacqua, Bhavwanti Sheth, Roberta Fiume, Massimiliano Pagani, Sergio Abrignani & Nullin Divecha, 2021, Proceedings of the National Academy of Sciences, 118(31), e2010053118

DOI: 10.1073/pnas.2010053118

Type: article

Modulating phosphoinositide profiles as a roadmap for treatment in acute myeloid leukemia

S. Ratti, C. Evangelisti, S. Mongiorgi, A. De Stefano, A. Fazio, F. Bonomini, M.Y. Follo, I. Faenza, L. Manzoli, B. Sheth, M.C. Vidalle, S.T. Kimber, N. Divecha, L. Cocco & R. Fiume, 2021, Frontiers in Oncology, 11

DOI: 10.3389/fonc.2021.678824

Type: article

Exploring the controversial role of PI3K signalling in CD4+ regulatory T (T-Reg) cells

Alessandro Poli, Roberta Fiume, Sara Mongiorgi, Antonio Zaurito, Bhavwanti Sheth, Magdalena Castellano Vidalle, Shidqiyyah Abdul Hamid, Scottt. Kimber, Francesca Campagnoli, Stefano Ratti, Isabella Rusciano, Irene Faenza, Lucia Manzoli & Nullin Divecha, 2020, Advances in Biological Regulation, 76, 100722

DOI: 10.1016/j.jbior.2020.100722

Type: article

Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin

Emily H. Bowler, Alex Smith-Vidal, Alex Lester, Joseph Bell, Zhenghe Wang, Christopher Bell, Yihua Wang, Nullin Divecha, Paul Skipp & Rob M. Ewing, 2019, Epigenetics, 15(1-2), 107-121

DOI: 10.1080/15592294.2019.1656154

Type: article