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Research project

Prof Keith Fox BBSRC Scibs Triplex SoBS

Staff

Lead researchers

Emeritus Professor Keith Fox

Research interests
  • DNA Interactions
  • Triplex DNA
  • Quadruplex DNA
Connect with Keith

Email: K.R.Fox@soton.ac.uk

Other researchers

Professor Lindy Holden-Dye BSc, MSc, PhD, FRSB, FBPhS

PROFESSOR OF NEUROSCIENCES
Research interests
  • Neuropharmacology
  • Invertebrate neuroscience
  • Nematode neurobiology
Connect with Lindy

Email: L.M.Holden-Dye@soton.ac.uk

Research outputs

2?-aminoethoxy-2-amino-3-methylpyridine in triplex-forming oligonucleotides: high affinity, selectivity and resistance to enzymatic degradation
Chenguang Lou, Montserrat Shelbourne, Keith R. Fox & Tom Brown, 2011, Chemistry - A European Journal, 17(52), 14851-14856
DOI: 10.1002/chem.201102287
Type: article
Formation of stable DNA triplexes
Keith R. Fox & Tom Brown, 2011, Biochemical Society Transactions, 39(2), 629-634
DOI: 10.1042/BST0390629
Type: article
CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides
Simon R. Gerrard, Mastoura M. Edrees, Imenne Bouamaied, Keith R. Fox & Tom Brown, 2010, Organic & Biomolecular Chemistry, 8(22), 5087-5096
DOI: 10.1039/c0ob00119h
Type: article
Synthesis and properties of triplex-forming oligonucleotides containing 2'-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine
Chenguang Lou, Qiang Xiao, Lavinia Brennan, Mark E. Light, Nuria Vergara-Irigaray, Elizabeth M. Atkinson, Lindy M.. Holden-Dye, Keith R. Fox & Tom Brown, 2010, Bioorganic & Medicinal Chemistry, 18(17), 6389-6397
DOI: 10.1016/j.bmc.2010.07.005
Type: article
Potent triple helix stabilization by 5?,3?-modified triplex-forming oligonucleotides
Nouha Ben Gaied, Zhengyun Zhao, Simon R. Gerrard, Keith R. Fox & Tom Brown, 2009, ChemBioChem, 10(11), 1839-1851
DOI: 10.1002/cbic.200900232
Type: article
DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine
David A. Rusling, Guomei Peng, Natarajan Srinivasan, Keith R Fox & Tom Brown, 2009, Nucleic Acids Research, 37(4), 1288-1296
DOI: 10.1093/nar/gkn1060
Type: article
DNase I footprinting
Antonia S. Cardew & Keith R. Fox, 2009
DOI: 10.1007/978-1-60327-418-0_10
Type: bookChapter