Research project

Small molecule stabilisers/activators of p53 mutants

Research groups:

Chemical Biology, Diagnostics and Therapeutics
Lead researchers:

Dr Matthias Baud
Research funder:

Royal Society
Status:

Not active

Staff

Lead researchers

Dr Matthias Baud

Associate Professor

Research interests

Chemical Biology
Medicinal Chemistry
Protein Sciences

Connect with Matthias

Email: M.Baud@soton.ac.uk

Collaborating research institutes, centres and groups

Chemical Biology, Diagnostics and Therapeutics

We investigate the properties of biomolecules – including an assortment of DNA, proteins, lipids and carbohydrates.

Research outputs

Discovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C

Joseph Richard Stephenson Clarke, Leon R Douglas, Patrick Duriez, Dimitrios-Ilias Balourdas, Andreas C. Joerger, Raniya Khadiullina, Emil Bulatov & Matthias G.J. Baud, 2022, ACS Pharmacology and Translational Science, 5(11), 1169–1180

DOI: 10.1021/acsptsci.2c00164

Type: article

Key players in the mutant p53 team: small molecules, gene editing, immunotherapy

Vitaly Chasov, Regina Mirgayazova, Ekaterina Zmievskaya, Raniya Khadiullina, Aygul Valiullina, Joseph Richard Stephenson Clarke, Albert Rizvanov, Matthias G.J. Baud & Emil Bulatov, 2020, Frontiers in Oncology, 10

DOI: 10.3389/fonc.2020.01460

Type: review