Research
Research interests
- Effect of early embryo environment on postnatal long-term health
Current research
We are interested in how the environment of the oocyte and preimplantation embryo can influence its development and long-term potential. We investigate in mouse models how maternal diet (in vivo), maternal sickness (in vivo) or IVF-related culture conditions (in vitro) can affect blastocyst development. We examine lifetime consequences of preimplantation environment on fetal growth, placental function, postnatal growth, brain development and behaviour, cardiovascular and metabolic physiology, and immune reactivity.
We collaborate locally with staff within Biological Sciences; Developmental Physiology and Medicine; Centre for Developmental Origins of Health and Disease, notably Dr Sandrine Willaime-Morawek, Dr Neil Smyth, Professor Ying Cheong.
Research projects
Completed projects
Researchers:
Sponsor: Biotechnology & Biological Sciences Research Council
Researchers:
Sponsor: Biotechnology & Biological Sciences Research Council
Researchers:
Sponsor: Biotechnology & Biological Sciences Research Council
Researchers:
Sponsor: National Institutes of Health
Researchers:
Sponsor: European Union
Researchers:
Sponsor: European Union
Researchers:
Sponsor: The Infertility Research Trust