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Research project

Functionalized Magnetic Resonance Beacons for Enhanced Spectroscopy and Imaging

Project overview

Development and demonstration of molecular agents called functional magnetic resonance beacons (fMRBs). These agents support hyperpolarized spin order locked into long-lived states which may be converted into strong NMR signals upon activation by a physical, chemical, or biochemical signal.

Staff

Lead researchers

Professor Malcolm Levitt

Professor of Chemistry
Research interests
  • Magnetic Resonance
  • Endofullerenes
Connect with Malcolm

Email: mhl@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs

Error compensation without a time penalty: robust spin-lock-induced crossing in solution NMR
Mohamed Sabba, Christian Bengs, Urvashi D. Heramun & Malcolm H. Levitt, 2026, Journal of Physical Chemistry Letters, 17(14), 4161-4166
DOI: 10.1021/acs.jpclett.6c00524
Type: article
Spinor double-quantum excitation in the solution NMR of near-equivalent spin-1/2 pairs
Urvashi D. Heramun, Mohamed Sabba, Dolnapa Yamano, Christian Bengs, Bonifac Legrady, Giuseppe Pileio, Sam Thompson & Malcolm H. Levitt, 2026, The Journal of Chemical Physics, 164(6)
DOI: 10.1063/5.0312298
Type: article
Weak nuclear spin singlet relaxation mechanisms revealed by experiment and computation’
Boris Kharkov, Xueyou Duan, Jyrki JS Rantaharju, Mohamed Sabba, Malcolm H. Levitt, James W. Canary & Alexej Jerschow, 2022, Physical Chemistry Chemical Physics, 24(12), 7531-7538
DOI: 10.1039/D1CP05537B
Type: article
Direct production of a hyperpolarized metabolite on a microfluidic chip
Sylwia, Joanna Barker, Laurynas Dagys, William G Hale, Barbara H Ripka, James Eills, Manvendra Sharma, Malcolm H. Levitt & Marcel Utz, 2022, Analytical Chemistry, 94(7), 3260-3267
DOI: 10.1021/acs.analchem.1c05030
Type: article
Low-Frequency Excitation of Singlet-Triplet Transitions. Application to Nuclear Hyperpolarization
Laurynas Dagys, Christian Bengs & Malcolm H. Levitt, 2021, The Journal of Chemical Physics, 155(15), 1-9
DOI: 10.1063/5.0065863
Type: article
Generalised magnetisation-to-singlet-order transfer in nuclear magnetic resonance
Christian Bengs, Mohamed Sabba, Alexej Jerschow & Malcolm H. Levitt, 2020, Physical Chemistry Chemical Physics, 22(17), 9703-9712
DOI: 10.1039/D0CP00935K
Type: article
Fast destruction of singlet order in NMR experiments
Bogdan A. Rodin, Kirill F. Sheberstov, Alexey S. Kiryutin, Lynda J. Brown, Richard C.D. Brown, Mohamed Sabba, Malcolm H. Levitt, Alexandra V. Yurkovskaya & Konstantin L. Ivanov, 2019, The Journal of Chemical Physics, 151(23)
DOI: 10.1063/1.5131730
Type: article