Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Yi Ying Ong, Mya-Thway Tint, Izzuddin M. Aris, Wen Lun Yuan, Ling-Wei Chen, Marielle V. Fortier, Jonathan T.L. Choo, Lieng Hsi Ling, Lynette P. Shek, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith Godfrey, Mary F.F. Chong, Shiao-Yng Chan, Johan G. Eriksson, Mary E. Wlodek, E. De Lucia Rolfe, Ken K Ong, Navin Michael & Yung Seng Lee,
2022, International Journal of Epidemiology, 51(6), 1835-1846
DOI: 10.1093/ije/dyac154
Type: article
Chandni Maria Jacob, Mark Hanson, Hazel Inskip & Wendy Lawrence,
2022, Nutrients, 14(17)
DOI: 10.3390/nu14173623
Type: article
Kathryn R. Hesketh, Soren Brage, Hazel Inskip, Sarah Crozier, Keith Godfrey, Nicholas Harvey, Cyrus Cooper & Esther M.F. van Sluijs,
2022, Journal of Physical Activity and Health, 19(8), 558 - 565
Type: article
Chandni Maria Jacob & Mark Hanson,
2022, Practical Diabetes, 39(4)
DOI: 10.1002/pdi.2404
Type: article
Yi Ying Ong, Wei Wei Pang, Jonathan Y. Huang, Izzuddin M. Aris, Suresh Anand Sadananthan, Tint Mya, Wen Lun Yuan, Ling-Wei Chen, Yiong Huak Chan, Neerja Karmani, Sendhil Velan, Marielle V. Fortier, Jonathan T.L. Choo, Lieng Hsi Ling, Lynette Shek, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith Godfrey, Mary F.F. Chong, Shiao-Yng Chan, Johan G. Eriksson, Mary E. Wlodek, Yung Seng Lee & Navin Michael,
2022, European Journal of Nutrition, 61(5), 2383-2395
Type: article
Daniella Watson, Chandni Maria Jacob, Gareth Giles, Fionnuala M. McAuliffe, Keith Godfrey & Mark Hanson,
2022, Reproductive, Female & Child Health
DOI: 10.1002/rfc2.8
Type: article
Karen Mei Ling Tan, Mya Thway Tint, Narasimhan Kothandaraman, Fabian Yap, Keith Godfrey, Yung Seng Lee, Kok Hian Tan, Peter D. Gluckman, Yap Seng Chong, Mary F.F. Chong, Johan G. Eriksson & David Cameron-Smith,
2022, International Journal of Obesity, 46(6), 1128-1137
Type: article