Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Le Duc Huy Ta, Carina Jing Xuan Tay, Christophe Lay, Paola Florez de Sessions, Cheryl Pei-Ting Tan, Michelle Jia-Yu Tay, Hui Xing Lau, Atiqa Binte Zulkiffi, Gaik Chin Yap, Elizabeth Huiwen Tham, Eliza Xin Peri Ho, Anne Eng Neo Goh, Keith Godfrey, Johan G. Eriksson, Jan Knol, Peter D. Gluckman, Yap-Seng Chong, Jerry Kok Yen Chan, Kok Hian Tan, Kok Wee Chong, Si Hui Goh, Zai Ru Cheng, Bee Wah Lee, Lynette P. Shek & Evelyn X.L. Loo,
2021, Environmental Microbiology Reports
Type: article
Evelyn Xiu-Ling Loo, Hui Xing Lau, Noor Hidayatul Aini Suaini, Lydia Su Yin Wong, Anne Eng Neo Goh, Oon Hoe Teoh, Hugo van Bever, Lynette Pei-Chi Shek , Bee Wah Lee, Kok Hian Tan, Keith Godfrey, Johan Gunnar Eriksson, Yap-Seng Chong & Elizabeth Huiwen Tham,
2021, Pediatric Allergy and Immunology, 32(5), 1096-1099
DOI: 10.1111/pai.13493
Type: letterEditorial
Tint Mya, Navin Michael, Suresh Anand Sadananthan, Jonathan Y. Huang, Chin Meng Khoo, Keith Godfrey, L.P.C. Shek, Ngee Lek, Kok Hian Tan, Fabian Yap, Sendhil Velan, Peter D. Gluckman, Yap-Seng Chong, Neerja Karnani, Shiao-Yng Chan, Melvin Khee-Shing Leow, Kuan Jin Lee, Yung Seng Lee, H. Hu, Cuilin Zhang, M.V. Fortier & Johan G. Eriksson,
2021, Journal of Clinical Endocrinology & Metabolism, 106(10), 2901-2914
Type: article
Natarajan Padmapriya, Mya Thway Tint, Suresh Anand Sadananthan, Navin Michael, Bozhi Chen, Shirong Cai, Jia Ying Toh, Carla Lanca, Kok Hian Tan, Seang Mei Saw, Lynette Shek, Yap-Seng Chong, Peter D. Gluckman, Yung Seng Lee, Fabian Yap, Marielle V. Fortier, Mary Foong-Fong Chong, Keith Godfrey, Johan G. Eriksson, Sendhil Velan, Michael S. Kramer, Jonathan Y. Bernard & Falk Müller-Riemenschneider,
2021, International Journal of Obesity, 45(9), 1995-2005
Type: article
Danielle Schoenaker, Judith Stephenson, Anne Connolly, Sally Shillaker, Sarah Fishburn, Mary Barker, Keith Godfrey & Nisreen Alwan,
2021, Journal of Developmental Origins of Health and Disease
Type: article
Arve Ulvik, Adrian McCann, Oivind Midttun, Klaus Meyer, Keith Godfrey & Per M Ueland,
2021, Analytical Sciences, 93(21), 7616-7624
Type: article
Yi Ying Ong, Jonathan Y. Huang, Navin Michael, Suresh Anand Sadananthan, Wen Lun Yuan, Ling-Wei Chen, Neerja Karnani, Sendhil Velan, Marielle V. Fortier, Kok Hian Tan, Peter D. Gluckman, Fabian Yap, Yap-Seng Chong, Keith Godfrey, Mary Foong-Fong Chong, Shiao-Yng Chan, Yung Seng Lee, Mya Thway Tint & Johan G. Eriksson,
2021, Journal of Clinical Endocrinology & Metabolism, 106(5), E2015-E2024
Type: article