Publications

Explore our research outputs and impact in-depth.

Research outputs

Fcγ receptor binding is required for maximal immunostimulation by CD70-Fc

Osman Dadas, Joel D. Allen, Sarah L. Buchan, Jinny H. Kim, H.T. Claude Chan, C. Ian Mockridge, Patrick J. Duriez, Anne Rogel, Max Crispin & Aymen Al-Shamkhani, 2023, Frontiers in Immunology, 14

DOI: 10.3389/fimmu.2023.1252274

Type: article

Serum immunoglobulin and the threshold of Fc receptor-mediated immune activation

Hannah Bauer-Smith, Abigail S.L. Sudol, Stephen A. Beers & Max Crispin, 2023, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1867(11)

DOI: 10.1016/j.bbagen.2023.130448

Type: article

Reducing affinity as a strategy to boost immunomodulatory antibody agonism

Xiaojie Yu, Christian Orr, H.T. Claude Chan, Sonya James, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Jonathan W. Essex, Ivo Tews, Martin J. Glennie & Mark Cragg, 2023, Nature, 614(7948), 539-547

DOI: 10.1038/s41586-022-05673-2

Type: article

Fc-γ receptor-mediated crosslinking co-defines the immunostimulatory activity of anti-human CD96 antibodies

Anne Rogel, Fathima M Ibrahim, Stephen Thirdborough, Florence Renart-Depontieu, Charles Birts, Sarah Buchan, Xavier Preville, Emma King & Aymen Al-Shamkhani, 2022, JCI Insight, 7(19)

DOI: 10.1172/jci.insight.158444

Type: article

A randomized, double-blind, biomarker-selected, phase II clinical trial of maintenance poly ADP-ribose polymerase inhibition with rucaparib following chemotherapy for metastatic urothelial carcinoma

Simon J. Crabb, Syed Hussain, Eileen Soulis, Samantha Hinsley, Laura Dempsey, Avril Trevethan, YeePei Song, Jim Barber, John Frew, Joanna Gale, Guy Faust, Susannah Brock, Ursula McGovern, Omi Parikh, Deborah Enting, Santhanam Sundar, Gihan Ratnayake, Kathryn Lees, Alison J Birtle, Thomas Powles & Robert J Jones, 2022, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 41(1), 54-64

DOI: 10.1200/JCO.22.00405

Type: article

Prognostic significance of crown-like structures to trastuzumab response in patients with primary invasive HER2 + breast carcinoma

Charles N. Birts, Constantinos Savva, Stéphanie A. Laversin, Alicia Lefas, Jamie Krishnan, Aron Schapira, Margaret Ashton-Key, Max Crispin, Peter W.M. Johnson, Jeremy P. Blaydes, Ellen Copson, Ramsey I. Cutress & Stephen A. Beers, 2022, Scientific Reports, 12(1)

DOI: 10.1038/s41598-022-11696-6

Type: article

Immune responses to SARS-CoV-2 variants after two and three doses of vaccine in B-cell malignancies

Sean H. Lim, Beth Stuart, Debora Joseph-Pietras, Marina Johnson, Nicola Campbell, Adam Kelly, Danielle Jeffrey, Anna H Turaj, Kate Rolfvondenbaumen, Celine Galloway, Thomas Wynn, Adam R. Coleman, Benjamin Ward, Karen Long, Helen Coleman, Carina Mundy, Andrew T. Bates, Diana Ayres, Robert Lown, Janlyn Falconer, Oliver Brake, James Batchelor, Victoria Willimott, Anna Bowzyk Al-Naeeb, Lisa Robinson, Ann O'Callaghan, Graham P Collins, Tobias Menne, Saul N Faust, Christopher P Fox, Matthew Ahearne, Peter W M Johnson, Andrew J Davies & David Goldblatt, 2022, Nature cancer, 3(5), 552-564

DOI: 10.1038/s43018-022-00364-3

Type: article