Project overview
This application aims to determine: early biomarkers of cardiovascular disease (CVD) risk at birth/during childhood; the window(s) when early life interventions to reduce the risk of obesity and CVD are most effective; and the nature of potentially effective intervention(s). In the Southampton Women's Survey (SWS) prospective preconception cohort, we have discovered perinatal epigenetic biomarkers of later CVD risk in mechanistically relevant genes, now confirmed in our other cohorts. We will determine how these biomarkers relate to the trajectory of adiposity, cardiovascular structure, function and fitness in SWS children to age 12yrs. Using SWS samples collected at birth and age 12yrs we will extend our panel of epigenetic biomarkers and investigate interactions with fixed genetic variants in relation to CVD risk. Then we will relate the resulting biomarker panel to CVD risk in children from ongoing cohorts in which pre- or post-natal interventions to modify risk factors are being made.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
N. Robinson, H. Brown, Elie Antoun, Keith Godfrey, Mark Hanson, Karen Lillycrop, Sarah Crozier, Robert Murray, M.S. Pearce, C.L. Relton, V. Albani & J.A. McKay,
2021, Clinical Epigenetics, 13(1)
Type: article
See Ling Loy, Chee Wai Ku, Ada En Qi Lai, Xin Hui Choo, Angela Hui Min Ho, Yin Bun Cheung, Keith Godfrey, Yap-Seng Chong, Peter D. Gluckman, Lynette Pei-Chi Shek , Kok Hian Tan, Fabian Yap, Shiao-Yng Chan & Jerry Kok Yen Chan,
2021, Fertility and Sterility, 115(1), 138-147
Type: article
Anne H.Y. Chu, Rohan Lewis & Keith Godfrey,
2021, International Journal of Obesity, 45(1), 247-257
Type: article
Anne H.Y. Chu, I.M. Aris, Sharon Ng, Jonathan Y. Bernard, Tint Mya, Wen Lun Yuan, Keith Godfrey, Jerry Kok Yen Chan, Lynette P. Shek, Yap-Seng Chong, K.H. Tan, Seng Bin Ang, H.H. Tan, Bernard SM Chern, Fabian Yap, Yung Seng Lee, Ngee Lek, Melvin Khee-Shing Leow, Chin Meng Khoo & Shiao-Yng Chan,
2020, Scientific Reports, 10(1)
Type: article
Delicia Shu-Qin Ooi, Cheryl Pei-Ting Tan, Michelle Jia-Yu Tay, Siong Gim Ong, Elizabeth Huiwen Tham, Kewin Tien Ho Siah, Johan Gunnar Eriksson, Keith Godfrey, Lynette Pei-Chi Shek & Evelyn Xiu-Ling Loo,
2020, Journal of Developmental Origins of Health and Disease, 11(6), 545-556
Type: article
Evelyn X.L. Loo, S.E. Soh, See Loy, Sharon Ng, M.T. Tint, Shiao-Yng Chan, Jonathan Y. Huang, Fabian Yap, K.H. Tan, Bernard S.M. Chern, H.H. Tan, Michael Meaney, Neerja Karnani, Keith Godfrey, Yung Seng Lee, Jerry Kok Yen Chan, Peter D. Gluckman, Y-S Chong, Lynette P. Shek & Johan G. Eriksson,
2020, European Journal of Epidemiology
Type: article
Reshma Appukuttan Pillai, Mohammed Omedul Islam, Preben Selvam, Neha Sharma, Anne HY Chu, Oliver C. Watkins, Keith Godfrey, Rohan Lewis & Shiao-Yng Chan,
2020, Journal of Clinical Endocrinology & Metabolism, 106(2), e875–e890
Type: article