Breadcrumb
Research Group
Cell and Developmental Biology
We research how cells become specialised, communicate with each other and respond to the environment, leading to an impact on the development of cancer, neurological diseases and the function of the immune system.
Part of
About
Our research provides a natural training environment for the next generation of scientists by combining molecular, biochemical, gene editing and imaging approaches with structural biology. This enables advanced investigations into the complex mechanisms of fundamental biology.
We pursue a range of interests including:
- the molecular organisation of proteins and nucleic acids
- cell signalling pathways controlling gene expression, autophagy and cell growth
- mechanisms of chromosome segregation
- the structure and function of the immune system, plant growth and environmental interactions
- membrane proteins and cellular function
Our research provides experimental platforms to collaborate with other researchers in other areas. For instance, we work with our colleagues in medicine to exploit structural and functional studies on how cancer cells evade the immune system.
Supercharging your immune system
Research led by Professor Nullin Divecha and his laboratory team has identified a way to boost the power of the human immune system to find and destroy cancer cells within the body.
People, projects and publications
People
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Research projects
Research project
IfLS Pilot Project: Multiplex in situ imaging and deep learning to investigate the contribution of abnormal cell divisions to breast tumour heterogeneity
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Investigating the role of oriented cell divisions in mammary epithelial morphogenesis and homeostasis using human organoids
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MRF Skills Training And Development Award
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Preclinical evaluation of potential therapeutic targets (Project 2)
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Role of autophagy in oncogenic RAS-induced invasive behaviour
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The Genetics and Developmental Biology of Cell Division in Mammary Stem Cells
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The Gerald Kerkut Charitable Trust PhD Studentship: The genetics and developmental biology of cell division in mammary stem cells
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The interactome of TRPA1 in Idiopathic Pulmonary Fibrotic Lung Fibroblasts
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The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)
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TURKISH EMBASSY Education Counsellor’s Office-PhD studentship
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Publications
Chia-Hung Chen, Bo-Wei Wang, Yu-Chun Hsiao, Chun-Yi Wu, Fang-Ju Cheng, Te-Chun Hsia, Chih-Yi Chen, Yihua Wang, Zhang Weihua, Ruey-Hwang Chou, Chih-Hsin Tang, Yun-Ju Chen, Ya-Ling Wei, Jennifer Hsu, Chih-Yen Tu, Mien-Chie Hung & Wei-Chien Huang,
2021, Oncogene, 40, 4796–4808
Type: article
Pooja Khurana, Neil Smyth, Bhavwanti Sheth, Miguel abraham A Velazquez, Judith Eckert & Thomas Fleming,
2021, Journal of Developmental Origins of Health and Disease, 1-11
Type: article
Yuan Yuan, Yali Li, Guoqiang Qiao, Yilu Zhou, Zijian Xu, Charlotte Hill, Zhenglin Jiang & Yihua Wang,
2021, Frontiers in Molecular Biosciences, 8
Type: article
Sumei Yao, Ayse Ertay, Yilu Zhou, Liudi Yao, Charlotte Hill, Jinliang Chen, Yangbo Guan, Hui Sun, Robert Ewing, Yifei Liu, Xuedong Lv & Yihua Wang,
2021, Frontiers in Oncology, 11
Type: article
Salah Elias,
2021, Cell Stem Cell, 802-805
Type: letterEditorial
Xiaojun Wu, Xiaofan Liu, Yilu Zhou, Hongying Yu, Ruiyun Li, Qingyuan Zhan, Fang Ni, Si Fang, Yang Lu, Xuhong Ding, Hailing Liu, Robert Ewing, Mark Jones, Yi Hu, Hanxiang Nie & Yihua Wang,
2021, The Lancet Respiratory Medicine
Type: article
Luciana E. Bostan, Claire E Clarkin, Mohamed Mousa, Peter R Worsley, Daniel L. Bader, Jonathan I. Dawson & Nicholas D. Evans,
2021, ACS Biomaterials Science & Engineering, 7(6), 2716-2722
Type: article
Yilu Zhou, Charlotte Hill, Liudi Yao, Juanjuan Li, David Hancock, Julian Downward, Mark Jones, Donna Davies, Robert Ewing, Paul Skipp & Yihua Wang,
2021, Frontiers in Molecular Biosciences, 8
Type: article
Aikta Sharma, Alice L Goring, Peter Johnson, Alan Boyde, R.J. Emery, Eric Hesse, Bjorn Olsen, A.A. Pitsillides, Richard Oreffo, Sumeet Mahajan & Claire Clarkin,
2021, Disease Models and Mechanisms, 14(3)
DOI: 10.1242/dmm.048116
Type: article
Daniel J. Klionsky, J. Arjuna Ratnayaka, David Tumbarello, Yihua Wang & Daniel Kaganovich,
2021, Autophagy, 17(1), 1-382
Type: review
Pagination
I am a T cell immunologist. I am interested in how early innate immune responses - particularly neutrophil infiltration and antimicrobial peptide production - affect T cell differentiation and function.