Biosensors and Diagnostics

Module overview

A biosensor is a device that translates a biomolecular binding event into an electrical or optical signal that can be quantified and recorded. Biosensors come in many different formats, from complicated nanofabricated mechanical transducers to simple but effective paper diagnostics. This module introduces the core principles of biosensor design, including biomolecule immobilisation, transduction mechanisms, and the quantitative approaches used to select biomarkers and optimise sensor performance. You will also learn how quantitative and computational methods are used to design biosensor systems (for example bioinformatics for identifying protein biomarkers) and to measure diagnostic performance and support clinical decision-making. Through lectures, weekly tutorials, and a laboratory practical, you will connect theoretical concepts to real-world bio-sensing applications.

Aims and Objectives

Learning Outcomes

Knowledge and Understanding

Having successfully completed this module, you will be able to demonstrate knowledge and understanding of:

The principle of operation of a wide variety of diagnostic devices paper based on microfluidics, nanopore DNA sequencing, droplet microfluidics for genetic analysis and single cell analytics, and DNA microarray technology.
The role of biomarker selection and quantitative data in biosensor performance.
Biosensor design, biofunctionalisation of surfaces, biosensor transducer technologies.

Subject Specific Intellectual and Research Skills

Having successfully completed this module you will be able to:

Critically evaluate biosensor data from the scientific literature.
Appreciate the advantages and limitations of specific diagnostic systems.
Explain the working mechanisms of the most common types of biosensors.

Learning and Teaching

Teaching and learning methods

The module is delivered via a mixture of lectures, seminars and lab exercises that contribute towards a coursework output and a final exam.

Study time
Type	Hours
Wider reading or practice	44
Specialist Laboratory	3
Lecture	24
Completion of assessment task	12
Preparation for scheduled sessions	30
Revision	25
Tutorial	12
Total study time	150

Resources & Reading list

Textbooks

Eggins BR (2002). Chemical Sensors and Biosensors. Wiley.

Cooper MA (2009). Label-Free Biosensors: Techniques and Applications. Cambridge: Cambridge University Press.

Gorton L (2005). Biosensors and Modern Biospecific Analytical Techniques, Comprehensive Analytical Chemistry series. Elsevier.

Hames D and Hooper NM (2005). Biochemistry, 3rd Ed, BIOS Instant Notes series. Taylor and Francis.

Khanna VK (2012). Nanosensors: Physical, Chemical and Biological, Series in Sensors. Taylor and Francis.

Ferrier DR (2014). Biochemistry, 6th Ed, Lippincott's Illustrated Reviews. Wolters Kluwer.

Kumar S (2007). Nanomaterials for Biosensors, Nanotechnologies for the Life Sciences series. Wiley.

Zourob M (Ed.), (2010). Recognition Receptors in Biosensors. Springer.

Banica FG (2012). Chemical Sensors and Biosensors: Fundamentals and Applications. Wiley.

Gizeli E and Lowe CR (2002). Biomolecular Sensors. CRC Press.

Pethig RR and Smith S. Introductory Bioelectronics: for Engineers and Physical Scientists.

Assessment

Summative

This is how we’ll formally assess what you have learned in this module.

Breakdown
Method	Percentage contribution
Examination	80%
Specialist Laboratory	10%
Coursework	10%

Referral

This is how we’ll assess you if you don’t meet the criteria to pass this module.

Breakdown
Method	Percentage contribution
Examination	100%

Repeat

An internal repeat is where you take all of your modules again, including any you passed. An external repeat is where you only re-take the modules you failed.

Breakdown
Method	Percentage contribution
Examination	100%

Repeat Information

Repeat type: Internal & External