Project overview
This project will investigate the enzymatic glycosylation of modified carbohydrate monosaccharides to achieve larger, biologically relevant glycan structures. This will be achieved by extensive screening of glycosyltransferase enzymes (enzymes that catalyse the addition of a new monosaccharide to a growing sugar 'acceptor'), that are able to use modified sugars as the 'acceptor', but also as 'donor'. The biological relevance of the synthesised new type of glycan structures will be validated by investigating their binding profile to a range of proteins that are known to be of relevance in the health sciences, with the immediate aim to develop new diagnostics applications. However, depending on the array results, further applications in other areas in the health sciences are envisaged.
Staff
Other researchers
Collaborating research institutes, centres and groups
Research outputs
2020, Cell Chemical Biology, 27(9), 1199-1206.e5
Type: article
Pablo Valverde Sanchez, Jean B Vendeville, Kristian Hollingsworth, Ashley Mattey, Tessa Keenan, Harriet Chidwick, Helene Ledru, Kler Huonnic, Kun Huang, Mark Light, Nicholas Turner, Jesus Jimenez-Barbero, M. Carmen Galan, Martin A. Fascione, Sabine L. Flitsch, W. Bruce Turnbull & Bruno Linclau,
2020, Chemical Communications, 56(47), 6408-6411
DOI: 10.1039/d0cc02209h
Type: article
Claire Council, Kelly J. Kilpin, Jessica S Gusthart, Sarah A. Allman, Bruno Linclau & Seung Seo Lee,
2020, Organic & Biomolecular Chemistry, 18(18), 3423-3451
DOI: 10.1039/D0OB00436G
Type: article
2019, ACS Chemical Biology, 14(7), 1660-1671
Type: article
Julien GJ Malassis, Jean Vendeville, Qui-Hien Nguyen, Marie Boujon, Quentin Gaignard-Gaillard, Mark Light & Bruno Linclau,
2019, Organic & Biomolecular Chemistry
DOI: 10.1039/C9OB00707E
Type: article
Clement Q. Fontenelle, Ramakrishna Kuppala, Mark Light & Bruno Linclau,
2018, Carbohydrate Research, 455, 14-17
Type: article