Project overview
The proposal described below is fundamentally a new method of synthesising, screening and sequencing DNA at a rate that is thousands of time,, faster than existing methods. If successful it will allow over 4 billion bases to be sequenced in less than a day on one instrument! The magnitude what is being proposed here is quite literally mind-boggling and will cause a revolution in all areas of human health forever changing the landscape biological and medicinal sciences. En route spin off applications will include the rapid and comprehensive identification of all single base changes a given person's genome, the ability to analyse large numbers of people for the presence of single changes at an unprecedented rate, a method fl rapidly and cheaply producing huge numbers (100,000s) of defined oligonucleotide sequences, and the use of this methodology to change curren array technology as well as the ultimate aim of sequencing billions of bases a day.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
D. Holmes, J.K. She, P.L. Roach & H. Morgan,
2007, Lab on a Chip, 7(8), 1048-1056
DOI: 10.1039/b707507n
Type: article
Gabriel Cavalli, Shahanara Banu, Rohan T. Ranasinghe, Graham R. Broder, Hugo F.P. Martins, Cameron Neylon, Hywel Morgan, Mark Bradley & Peter L. Roach,
2007, Journal of Combinatorial Chemistry, 9(3), 462-472
DOI: 10.1021/cc060079p
Type: article
G.S. Galitonov, S. Birtwell, N.I. Zheludev & H. Morgan,
2006, Optics Express, 14(4), 1382-1387
DOI: 10.1364/OE.14.001382
Type: article
Gerald Weber, Niall Haslam, Nava Whiteford, Adam Prügel-Bennett, Jonathan Essex & Cameron Neylon,
2006, Nature Physics, 2(1), 55-59
DOI: 10.1038/nphys189
Type: article
Nava Whiteford, Niall Haslam, Gerald Weber, Adam Prugel-Bennett, Jonathan W. Essex, Peter L. Roach, Mark Bradley & Cameron Neylon,
2005, Nucleic Acids Research, 33(19), e171
DOI: 10.1093/nar/gni170
Type: article