Project overview
The project will develop a new micro-technology for label-free point of care (PoC) cell analysis, paying particular attention to accurate determination of low abundance cell populations for a five-part differential for full blood count (FBC). The FBC is the single most common clinical measurement used to provide information on a patient's health in almost every single disease, indicating the large commercial impact of the work proposed here. The project will also develop new low pressure, low power microfluidics, minimally invasive sample extraction and low-volume processing and new integrated electronics. We will also develop methods for meaningful information delivery to patient and doctor. The end-results will be solutions and know-how for implementation of a handheld PoC Full Blood Count (FBC) system, based on high speed single cell impedance spectroscopy in a microfluidic format. This project will provide breakthroughs in functionality, minaturisation and consumer acceptability to realise a true PoC FBC.
Staff
Lead researchers
Other researchers
Collaborating research institutes, centres and groups
Research outputs
Leukocyte analysis and differentiation using high speed microfluidic single cell impedance cytometry
David Holmes, David Pettigrew, Christian H. Reccius, James D. Gwyer, Cess van Berkel, Judith Holloway, Donna E. Davies & Hywel Morgan,
2009, Lab on a Chip, 9(20), 2881-2889
DOI: 10.1039/b910053a
Type: article
Tao Sun, Cees van Berkel, Nicolas G Green & Hywel Morgan,
2008, Microfluidics and Nanofluidics, 6, 179-187
Type: article
Tao Sun, Nicolas G Green & Hywel Morgan,
2008, Nano, 3(1), 55-63
Type: article