Research Research groups Member of: Clinical Neurosciences Research projects Active projects Novel Therapeutics for Vision Loss associated with Albinism Researchers: Doctor Helena Lee Doctor James Self , Doctor Arjuna Ratnayaka , Doctor Matthias Baud , Doctor Eloise Keeling Completed projects Medium through-put drug discovery for albinism Researchers: Doctor Eloise Keeling Doctor James Self Sponsor: Fight for Sight Publications 29 publications Page 1 of 3 A longitudinal study of the 5xFAD mouse retina delineates Amyloid beta (Ab)-mediated retinal pathology from age-related changes Savannah A. Lynn, Sudha Priya Soundara Pandi, Aida Sanchez‑Bretano, Anna Marie Muir, Lidia Parker, David S. Chatelet, Tutte Newall, Jennifer A. Scott, Eloise Keeling, Neil R. Smyth, Jay E. Self, Andrew J. Lotery, Helena Lee & J. Arjuna Ratnayaka, 2025, Alzheimer's Research & Therapy, 17(1) DOI: 10.1186/s13195-025-01784-w Type: article Early life pre-disposition to diet-induced retinal pathology Anna Marie Muir, Savannah A. Lynn, Eloise Keeling, Helen Griffiths, Sandrine Willaime-Morawek, Neil R. Smyth, Helena Lee, Andrew J. Lotery & J. Arjuna Ratnayaka, 2025, Investigative Ophthalmology & Visual Science, 66(8) Type: conference Studies in the 5xFAD mouse retina reveal chronic Amyloid-beta mediated effects, providing new insights into complex retinopathies J. Arjuna Ratnayaka, Savannah A. Lynn, Sudha Priya Soundara Pandi, Aida Sanchez-Bretano, Anna Marie Muir, Lidia Parker, David S. Chatelet, Tutte Newall, Eloise Keeling, Neil R. Smyth, James E. Self, Helena Lee, Andrew J. Lotery & Jenny A. Scott, 2025, Investigative Ophthalmology & Visual Science, 66(8) Type: conference Can a portable flash visual evoked potential (VEP) device identify chiasmal decussation anomalies in albinism? Eloise Keeling, Perry Carter, Abdi Malik Musa, Fatima Shawkat, Helena Lee & Jay E. Self, 2025, Diagnostics, 15(11) DOI: 10.3390/diagnostics15111395 Type: article Could a hand-held, visual electrophysiology device theoretically reduce diagnostic waiting times for complex eye conditions in the NHS? A Discrete Event Simulation (DES) modelling study Steffen Bayer, Daniel Garillo, Marion Penn, Maria (Mary) Chorozoglou, Sally Brailsford, Eloise Keeling, Fatima Shawkat, Perry Carter, Helena Lee & Jay E. Self, 2025, BMC Health Services Research, 25(1) DOI: 10.1186/s12913-025-12551-w Type: article Sigma-2 receptor modulator CT1812 alters key pathways and rescues retinal pigment epithelium (RPE) functional deficits associated with dry age-related macular degeneration (AMD) Britney N. Lizama, Eloise Keeling, Eunah Cho, Evi M. Malagise, Nicole Knezovich, Lora Waybright, Emily Watto, Gary Look, Valentina Di Caro, Anthony O Caggiano, J. Arjuna Ratnayaka & Mary E Hamby, 2025, Scientific Reports, 15(1) DOI: 10.1038/s41598-025-87921-9 Type: article Molecular and cellular mechanisms of levodopa-mediated visual function rescue in albinism Sarah Macdonald, Eloise Keeling, Jennifer A Scott, Helen Griffiths, Andrew Lotery, J. Arjuna Ratnayaka, James Edward Self & Helena Lee, 2024, Investigative Ophthalmology & Visual Science, 65(7) Type: conference Human equivalent doses of l-DOPA rescues retinal morphology and visual function in a murine model of albinism Aida Sanchez-Bretano, Eloise Keeling, Jennifer A. Scott, Savannah A. Lynn, Sudha Priya Soundara-Pandi, Sarah L. Macdonald, Tutte Newall, Helen Griffiths, Andrew J. Lotery, J. Arjuna Ratnayaka, Jay E. Self & Helena Lee, 2023, Scientific Reports, 13 DOI: 10.1038/s41598-023-44373-3 Type: article Eyetracking-enhanced VEP for nystagmus Perry Carter, Fatima Shawkat, Jay Self, Helena Lee, Eloise Keeling & Matt Dunn, 2023, Investigative Ophthalmology & Visual Science, 64(8), 43 Type: article Use of a handheld electrophysiology device (RETeval, LKC) to identify visual pathway decussation defects Eloise Keeling, Perry Carter, Fatima Shawkat, Helena Lee & Jay Self, 2023, Investigative Ophthalmology & Visual Science, 64 Type: conference Pagination 1 2 3 Next page Next